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- PE-22-28
In stock, ships today
- Purity: ≥99% (HPLC)
- Independent lab report for the batch you receive
- For laboratory research use only
£35
- Only 8 left in the UK warehouse
- Order within 12h 10m for dispatch today, estimated delivery Thu 12 Nov
- Free UK delivery over £100
- Discreet, plain unbranded packaging
Third-party lab report
Batch PEX10.227 99% purity Tested 8 Jun 2026
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About PE-22-28
PE-22-28 is a synthetic peptide fragment derived from the activity-related sequence of spadin, designed to interact with TREK-1 (K2P2.1) potassium channels. It is investigated in preclinical and in vitro models as a truncated analogue for research into neurotrophic-related signalling cascades and neuronal cell research.
Primary areas of investigation
- TREK-1 channel research
- Potassium channel signalling studies
- MAPK/ERK cascade investigation
- PI3K/Akt pathway research
- BDNF-related signalling models
- Neuronal cell culture studies
Mechanism
Research into PE-22-28 examines its inhibition of TREK-1 potassium channels in experimental systems, with associated influence on BDNF-related signalling pathway research. Studies focus on its interaction with downstream MAPK/ERK and PI3K/Akt signalling cascade research. The exact binding profile and full mechanistic interactions remain under investigation in controlled cellular models.
Delivery and returns
Shipped in plain, unbranded packaging from our United Kingdom warehouse. Damaged on arrival? Tell us within 48 hours and we’ll put it right. Shipping and returns
For laboratory research use only. Not for human or veterinary use.
