UK Tracked 24 Dispatch

Fast, tracked shipping from our UK facility. Place order by 2pm for Same Day Dispatch Mon-Fri.

Temperature-Controlled Storage

All peptides maintained at -20C to -22C prior to shipment.

5-Amino-1MQ 50mg

Neurological & Cellular

Price Range

£45.00

Bulk Analysis Discounts

Buy 2+

Save 5%

Buy 3+

Save 10%

• IN STOCK: READY FOR DISPATCH

View Research Bundles

Analysis Total

£45.00 GBP

Certificate of Analysis (COA)

DOWNLOAD LATEST HPLC VERIFICATION

Product Overview

5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a low-molecular-weight, membrane-permeable small molecule widely used in preclinical research as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is a cytosolic enzyme expressed primarily in liver, adipose, and skeletal muscle tissue and is implicated in the regulation of cellular energy metabolism, nicotinamide turnover, and methyl-donor utilization. As a quinolinium derivative rather than a peptide-based inhibitor, 5-Amino-1MQ readily enters cells and serves as a research tool for investigating NNMT-mediated metabolic pathways and their downstream effects on intracellular NAD+ homeostasis.

Mechanism of Research

5-Amino-1MQ functions as a competitive inhibitor of NNMT, the enzyme responsible for catalyzing the methylation of nicotinamide (NAM) to 1-methylnicotinamide (1-MNA) using S-adenosyl-L-methionine (SAM) as a methyl donor. Inhibition of NNMT in experimental models has been shown to: Reduce the conversion of NAM to 1-MNA. Preserve intracellular NAM availability. Alter SAM utilization dynamics. These biochemical changes are associated, in preclinical systems, with increased NAD+ availability via the nicotinamide salvage pathway. Elevated NAD+ levels are hypothesized to influence NAD+-dependent signaling processes, including sirtuin activity, although these downstream effects remain under investigation and are not fully characterized across biological systems.

Primary Areas of Investigation

NNMT inhibition and adipocyte metabolism
Regulation of nicotinamide and NAD+ salvage pathways
NAD+-dependent signaling pathways (including sirtuin activity)
Skeletal muscle metabolism and satellite cell biology
Energy expenditure and metabolic efficiency in preclinical models
Insulin sensitivity and glucose homeostasis in experimental systems

Product Specifications

Product Name

5-Amino-1MQ

CAS No.

42464-96-0

Catalogue Number

FP-5A1MQ-50

Molecular Formula

C₁₀H₁₁N₂⁺

Molecular Weight

~159.21g/mol

Purity

≥ 99.0% (HPLC)

Form

Orange to Off-Red Lyophilised Powder

Solubility

Limited solubility in water; soluble in polar aprotic solvents such as DMSO or ethanol for research applications.

Storage

Store lyophilised powder at -20°C for long-term stability; once reconstituted, store refrigerated at 2–8°C.

Disclaimer

This product is sold for in-vitro laboratory research purposes only. It is not a drug, food, or cosmetic and is not intended for human or veterinary consumption. All handling should be performed by qualified professionals in a controlled laboratory setting. Forge Peptides is not liable for any misuse of this product. By purchasing, you agree that you are a qualified researcher or a scientific professional.